Quantitative Studies of Hepatocytes in Periportal and Perivenous Zones of the Liver Lobules in Diabetic Rats
نویسندگان
چکیده
منابع مشابه
Preparation of isolated periportal or perivenous hepatocytes from rat liver.
There are a number of functional, metabolic differences between periportal and perivenous hepatocytes in the mammalian liver resulting from zonal differences in the activity of several enzymes, and possibly from morphological differences as well (1). Examples of key enzymes where the periportal/perivenous activity ratio is >1 are glucose-σ-phosphatase (2), phosphoenolpyruvate carboxykinase (3),...
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In order to examine the pathways of hepatic glycogen repletion in the periportal and perivenous zones of the liver, [1-13C]glucose (99% enriched) was infused intraduodenally into conscious, 24-h fasted rats for 3 h. The liver was then quickly perfused in situ, and the cytoplasmic contents of the periportal and perivenous hepatocytes were selectively sampled by modification of the dual-digitonin...
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ژورنال
عنوان ژورنال: International Journal of Zoological Research
سال: 2007
ISSN: 1811-9778
DOI: 10.3923/ijzr.2007.186.192